The aim of the project is to set up an innovative method of regeneration of large bone tissue loss in oncological patients, based on the use of scaffold for tissue engineering and in vivo tissue engineering (iTE.) In this method, after the first stage of removing the bone tumour, an advanced refillment element (spacer) releasing antibacterial medicines and supporting radio and/or chemotherapy will be implemented in the area of the bone loss.
Simultaneously, advanced bioactive and biodegradable scaffold will be ectopically injected into the patient’s body, in the area supporting the formation of new tissue. After the in vivo creation of new bone tissue, the spacer will be removed and a prefabricated tissue flap (a product of tissue engineering) will be grafted and implemented in the area of mandible loss, ensuring its physiological and aesthetic functionality. To achieve this aim, an advanced spacer, a bioactive scaffold and a method of supplying them with bioactive agents will be worked out.
The results of the project will be tested in vitro and in vivo on small and big animal models.